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KMID : 0368019950180010507
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Journal of Soonchunhyang University
1995 Volume.18 No. 1 p.507 ~ p.516
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Effect of Granulocyte Colony-Stimulating Factor (rhG-CSF: Neutorgin(r)) on Neutropenia Induced by Chemotherapy in Patients with non-Hodgkin's Lymphoma
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박성규
전진우/기신영/유병우/김홍수/백승호/원종호/홍대식/박희숙
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Abstract
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Clinical effects of rhG-CSF were investigated in 17 patients receiving chemotherapy for non-Hodgkin's lymphoma, Patients were given G-CSF 2μg/kg/day after 2nd cycle chemotherapy for least 14 consecutive days, and clinical and laboratory results
were
compared to results of the first cycle. Treatment with G-CSF resulted in increase of mean WBC count(952.9±152.2/mm3 vs 188.2±350.4mm3) and neutrophil count(212.9±53.0/mm3 vs 841.5±238.0/mm*), reduced the duration of leukocytopenic
days(12.4±1.3
days vs 5.5±1.0 days, WBC count less than 4000/mm*) and neutropenic days(4.5±0.9 days vs 2.3±0.7days, neutrophil count less than 500/mm*) , and reduced the duration of neutropenic fever(5.8±1.1 days vs 0.9±0.5 days). The side effects of
G-CSF
were
not so significant.
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KEYWORD
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